MACROBID

Drug Title

Macrobid (Nitrofurantoin)

Common use

Macrobid is a wide spectrum antibiotic. It inhibits construction of a bacterial cell wall, synthesis of a bacterial DNA and RNA, proteins, inhibits aerobic metabolism. This medication is used to treat bacterial infections of the urinary tract caused by E. Coli, Enterobacter cystitis, Staphylococcus aureus, and Enterococcus, Klebsiella such as pyelitis, pyelonephritis, cystitis, urethritis, to prevent infections during urological surgeries, cystoscopy, catheterization.

Macrobid is a sustained release macrocrystalline form of the antibiotic. Nitrofuranton is also available in a microcrystalline form (Furadantin), and a macrocrystalline form (Macrodantin). Absorption of the medication depends on the size of crystals and presence of food in the gastrointestinal tract.

Dosage and directions

Take 100 mg of Macrobid every 12 hours. Taking with a meal or milk increase its absorption and helps to avoid your stomach upset. Usual course of treatment continues seven days. Follow all recommendations of your doctor. Do not stop or start this medication without your doctor's permission.

Contraindications

Macrobid cannot be used in patients with kidney or liver failure, jaundice in history, glucose-6-phosphate dehydrogenase deficiency, acute porphyria, pregnancy, in children under 12 years of age. Breastfeeding should be interrupted when on Macrobid.

Drug interaction

High doses of probenecid (Benemid) or sulfinpyrazone (Anturane) can inhibit secretion by kidney channels and decrease urine levels of Macrobid. Consequently blood concentrations of Macrobid increases as well as the risk of toxicity. Antibacteral effect of Macrobid is reduced by nalidixic acid, while is absorption is decreased by antacids which contain magnesium trisilicate. Co-administration with quinolone antibiotics such as norfloxacin (Noroxin) reduces their effects.

Missed dose

If you miss a dose, take it as soon as you remember unless it is almost time of your next dose. If it is near the time of the next dose, skip the missed dose and return dosing schedule. Do not double the dose to make up the missed dose.

Overdose

Symptoms of overdose include nausea or vomiting. If you suppose that too much of Macrobid was taken seek immediate medical attention.

Storage

Store at room temperature in a tight container, away from moisture and humidity.