GLUCOVANCE

Drug Name

Glucovance (Metformin & Glyburide)

Common use

Glucovance is a combination of two orally taken drugs possessing a hyproglycemic effect which belong to two different groups: metformin and glibenclamide. Metformin belongs to biguanide class of substances and decreases blood levels of glucose by increasity susceptibility of peripheral tissues to action of insulin. Metmorfin decreases absorption of carbohydrates in gastrointestinal tract and inhibits synthesis of glucose in the liver. Glibenclamide is a derivate of sulfonylurea and acts stimulating secretion of insulin by β-cells of the pancreas. It is used along with a diet and exercise program to to treat type 2 diabetes (non-insulin-dependent diabetes).

Dosage and direction

Take Glucovance twice daily with meals and full glass of water. Take it regularly and each time every day to get the best benefit from it.

Drug interaction

Cimetidine (Tagamet) increases blood levels of Glucophage affecting its metabolism. Glucophage is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, ACE inhibitors (such as captopril), oxytetracycline, cyclophosphamide and salicylates increase the effects of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates. Azole antifungals (fluconazole) also interact with Glucovance.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Overdose

Symptoms of Glucovance overdose are ones of low blood sugar: hunger, tremors, confusion, irritability, drowsiness, headache, weakness, sweating, fast heartbeat, seizure and have a source of sugar at hand always. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.